ispg.org) agree that genetic testing for schizophrenia is premature at this stage, given the small odds ratios and inconsistent replications reviewed above. Until some as-yet unknown approach is achieved to combine large numbers of small effect genes into meaningful prediction algorithms, we are likely facing many more years
of research before acceptable testing for risk is possible. More hopefully, the uncommon but large effect CNVs on 22q, 15q, 16p, and 1q, that appear to Inhibitors,research,lifescience,medical be replicating fairly well in large datasets, may lead to tests that could identify molecular subtypes for at least a small percentage of schizophrenia cases. These molecular subtypes may in turn lead to better understanding of the pathogenesis Inhibitors,research,lifescience,medical of schizophrenia, and treatment might become more specific and individualized for these cases. Through the continued efforts of careful investigation in genetics of schizophrenia that embrace the nuances of phenotype and the latest technological developments, the field has an excellent chance to solve the etiologic puzzle of this enigmatic disorder.
Compulsive hoarding is a DAPT secretase ic50 syndrome characterized by excessive
Inhibitors,research,lifescience,medical collecting and saving behavior that results in a cluttered living space and significant distress or impairment.1 In the past decade, there has been a notable increase in research on hoarding, including its phenomenology, pathophysiology, and treatment Inhibitors,research,lifescience,medical approaches. This surge in interest has been coupled with contention regarding key aspects of the disorder. These controversies have led to exciting new research that has deepened our understanding of this complex syndrome. The aim of this article is to describe some of these debated issues, as well as to highlight recent advances in compulsive hoarding research. Diagnostic status An obvious example of a current debate within hoarding research is the question of where hoarding belongs
within our diagnostic nosology. The uncertainty regarding Inhibitors,research,lifescience,medical the most appropriate classification of compulsive hoarding syndrome has had important consequences for our understanding of hoarding, and in some ways has constituted an obstacle to hoarding research. The lack of clear placement within DSM has led to an underestimation of the significance of the burden of disease associated with compulsive hoarding, inconsistencies most with respect to an appropriate clinical comparison group in hoarding research, difficulties comparing findings across hoarding studies, and misconceptions regarding which assessment and treatment models are most relevant to hoarding. In the DSM-IV-TR,2 hoarding is described as difficulty discarding items, and is listed as one of the eight diagnostic criteria for obsessive-compulsive personality disorder (OCPD). Accumulating evidence, however, suggests that it is misleading and invalid to classify hoarding as part of OCPD.